Vitamin D and Omega-3 TriaL (VITAL Study):
VITAL investigated whether taking daily vitamin D3 and/or EPA+DHA (omega-3-acid ethyl esters) reduces the risk of major cardiovascular disease (CVD) events. These events were specifically defined as the composite of myocardial infarction (MI), stroke and CVD death. VITAL also looked at total invasive cancer in people who do not have a prior history of these illnesses. This is the first large-scale primary prevention trial — subjects included 25,871 men and women — looking at heart disease as an outcome.